Meta-analysis: Is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?

Table 4 Studies not included in meta-analysis

Ref.	Region	Publication	Participants	H. pylori infection Initial diagnosis⁄re-checking	Inventions (duration)	Cases	Follow-up (wk)	Eradication rate by ITT	First or second or three line therapy1
Graham et al[22], 1993	United States	Full text	Peptic ulcer	UBT and histology/UBT and histology	BAT 14	16	4	43%	1
Lobo et al[19], 1994	United Kingdom	Full text	NR	histology or culture /histology and culture	OAT 21 vs BT 28+M 14	17/26	4	58% vs 65%	1
Auriemma et al[34], 2001	Italy	Abstract	NR	NR/UBT	OAT 7	63	NR	77.3%	2
Perri et al[35], 2002	Italy	Full text	Dyspepsia	Histology and RUT/UBT	LAT 7 vs RBCAT 7 vs LAD 7	89/88/87	4-6	35% vs 20% vs 36%	1
Cammarota et al[25], 2004	Italy	Full text	NR	Culture/UBT	OBTA 7	89	8	91%	3
Sezgin et al[38],2007	Turkey	Full text	Dyspepsia or peptic ulcer	Histology and RUT and UBT/UBT	PA 7-PMT 7	32	4	50%	1
Buzás et al[39], 2008	Hungary	Full text	Duodenal ulcer	histology and RUT/UBT	PATN 14 vs PATB 14	22/19	6	62% vs 55%	3
Akyildiz et al[42], 2009	Turkey	Full text	NR	Histology and RUT/UBT	RBCAT 14/RBCAT 14	58/57	6	34.5% vs 36.8%	1
Cetinkaya et al[26], 2010	Turkey	Full text	Nonulcer dyspepsia	Histology/UBT	PA 5- PTM 9 vs PA5-PATM 9	56/56	6	82%/79%	1
Ataseven et al[43], 2010	Turkey	Full text	2-type Diabetes mellitus with H. pylori	Histology and RUT/UBT	PA 7-PTM 7	38	4	58%	1
Zhang[49], 2012	China	Full text	NR	RUT and UBT/UBT	EBAT	120	1 mo	93%	2
Tursi1 et al[52], 2012	Italy	Full text	peptic ulcer or gastritis or duodenitis	NR/RUT or UBT	PPI+A 5 - PPI+Le+T 5	119	1 mo	67%	3
Uygun et al[53], 2012	Turkey	Full text	nonulcerdyspepsia	Histology/UBT	PBA 7 - PBTM 7	142	45 d	81%	1
Kadayifci et al[48], 2012	Turkey	Full text	non-ulcerdyspepsia	Histology and UBT/UBT	EBAT 14/EATM 14	100/100	6	79%/74%	1
Liou et al[54], 2013	Taiwan	Full text	NR	UBT or two of RUT, histology and culture	EA 7- EMC 7 vs EA 7-EMT 7 vs EA 7 - EMLe 7	19/65/51	≥ 6	80%/71%/92%	3

¹Indicates first-line treatment for H. pylori; Indicates second-line treatment; Indicates third-line treatment. NR: Not reported; UBT: Urea breath test; RUT: Rapid urease test; O: Omeprazole; A: Amoxicillin; T: Tetracycline; B: Bismuth; C: Clarithromycin; M: Metrodinazole; P: Pantoprazole; E: Esomeprazole; L: Lansoprazole; D: Doxycycline; F: Furazolidone; Le: Levofloxacin; RBC: Ranitidine bismuth citrate.