Meta-analysis: Is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?

Table 1 Characteristics of included studies in quadruple

Ref.	Region	Publication	Participants	H. pylori infection Initial diagnosis ⁄re-checking	Inventions (duration)	Total (treatment/contrlo)	Follow-up (wk)	Eradication rate	Jadad scores
Luo[36], 2002	China	Full text	NR1	RUT/RUT	OBAT 7v OBCM 7	45/45	4	91% vs 56%	1
Chi et al[37], 2003	Taiwan	Full text	Dyspeptic patients	Histology or culture/UBT	OBAT 7v OBAM 7	50/50	6	78% vs 58%	3
Cheon et al[20], 2006	South Korea	Full text	Peptic ulcer	Histology or RUT or UBT/UBT	PBAT 7v PBMT 7	25/29	5	16% vs 66%	2
Uygun et al[40], 2008	Tuekry	Full text	Non-ulcer dyspeptic patients	Histology/histology and RUT	LBAT 14 v LBAM or LBMT 14	100/200	60 d	75% vs 73%	2
Wu et al[45], 2011	Taiwan	Full text	NR	RUT and histology or culture or UBT	EBTA 7 v EBTM 7	58/62	8	62% vs 81%	3
Chen et al[46], 2011	Chinese	Full text	Peptic ulcer and chronic gastritis	UBT/UBT	OATF 14/OBAC 14	60/60	4	92% vs 90%	2
Hu et al[23] , 2012	Taiwan	Abstract	NR	NR/UBT	RATM 10, /RBTM, 10	46/47	≥ 4	83% vs 87%	2
Liang et al[55], 2013	China	Full text	Functional dyspeptic patients and peptic ulcer	UBT/UBT	LBAT 14/LBTF, LBTM and LBAF 14	105/319	6	83.8% vs 91.5%	3
Our data1	China		Duodenal peptic	RUT/UBT	RBAT 10/RBAC 10	77/75	4	85.7% vs 81.3%

¹Unpublished data. NR: Not reported; UBT: Urea breath test; RUT: Rapid urease test; O: Omeprazole; A: Amoxicillin; T: Tetracycline; B: Bismuth; C: Clarithromycin; M: Metrodinazole; P: Pantoprazole; E: Esomeprazole; L: Lansoprazole; D: Doxycycline; F: Furazolidone; Le: Levofloxacin; RBC: Ranitidine bismuth citrate.