Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study

Table 5 Univariate and multivariate analyses of prognostic factors for disease-free survival

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Splenectomy	0.498 (0.314-0.792)	0.003	0.531 (0.341-0.828)	0.005
Gender, F	0.873 (0.476-1.601)	0.661
Age, > 60 yr	0.836 (0.395-1.769)	0.639
HBsAg, positive	1.634 (0.716-3.727)	0.243
AFP, > 400 ng/mL	1.386 (0.881-2.180)	0.158
Platelet count	0.994 (0.985-1.003)	0.221
White blood cell count	1.037 (0.993-1.083)	0.1
Tumor number, multiple	1.668 (0.862-3.226)	0.129
Tumor size, > 5 cm	0.785 (0.446-1.381)	0.401
Micro-vascular invasion	2.766 (1.700-4.498)	<0.001	2.642 (1.685-4.143)	< 0.001

HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein.