Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study

Table 4 Laboratory tests of the two groups after surgery

Variable	Pre-operation			1 d			1 wk			1 mo			1 yr
	HS	HA	P value	HS	HA	P value	HS	HA	P value	HS	HA	P value	HS	HA	P value
TBIL (μmol/L)	17.94 ± 7.34	16.62 ± 6.63	0.415	22.34 ± 8.52	32.72 ± 27.14	0.026	24.04 ± 10.90	34.06 ± 48.89	0.216	15.12 ± 5.28	15.87 ± 6.70	0.858	17.20 ± 6.21	18.61 ± 5.82	0.314
ALT (IU/L)	35.90 ± 16.89	39.24 ± 14,54	0.519	213.85 ± 187.27	348.00 ± 342.49	0.036	112.00 ± 101.69	169.57 ± 154.49	0.058	43.49 ± 23.78	49.41 ± 21.62	0.860	39.82 ± 17.85	41.11 ± 34.53	0.838
AST (IU/L)	39.92 ± 15.69	47.16 ± 27.63	0.162	244.49 ± 186.49	321.81 ± 314.90	0.194	80.64 ± 77.53	64.19 ± 37.23	0.246	49.41 ± 21.62	44.22 ± 22.31	0.306	47.69 ± 27.73	48.00 ± 48.75	0.973
PLT count (109/L)	61.43 ± 42.11	68.93 ± 17.68	0.134	98.54 ± 33.27	67.11 ± 21.67	< 0.001	230.95 ± 114.95	74.65 ± 26.05	< 0.001	214.18 ± 102.03	73.24 ± 24.12	< 0.001	199.97 ± 58.19	68.08 ± 36.52	< 0.001
WBC count (109/L)	3.96 ± 4.11	4.60 ± 4.41	0.332	16.30 ± 5.38	11.79 ± 4.07	< 0.001	10.93 ± 4.27	6.14 ± 2.74	< 0.001	6.48 ± 1.71	4.25 ± 1.41	< 0.001	5.96 ± 1.46	4.48 ± 2.02	< 0.001

Both PLT and WBC counts in the HS group were alleviated and were significantly higher when compared to those in the HA group at one day, one week, one month and one year postoperatively (P < 0.001) (Figure 3A and B). While levels of the TBIL and ALT were much higher in the HA group than in the HS group on postoperative day one (P < 0.05), and then descended as similar as the HS group (Figure 3C and D). The level of AST did not differ between the two groups. TBIL: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; WBC: White blood cell.