Anal cancer treatment: Current status and future perspectives

Table 1 Results of different treatment modalities in localized squamous cell anal cancer

	Protocol	CR	CFS	OS	DFS
A	RT	54%[29]	32% lower colostomy-free rate than C[28]	14% higher death rate than C[27]	12.9% higher death and relapse rates at 5 yr than C[27]
B	RT + 5-FU	NA	71%[29]	No significant difference from C	51%[29]
C	RT + 5-FU + Mitomycin	80%[29]89.6% at 26 wk[34]	59%[28]	78.3% at 5 yr[32,33]	67.8%[29,30]to 73%[29]
D	RT + 5-FU + Cisplatin	90.5% at 26 wk[34]	NA	70.7% at 5 yr[31,32]	57.8%[31,32]

NA: Not availiable; RT: Radiation therapy; 5-FU: 5-Fluorouracil; CR: Complete response; CFS: Colostomy-free survival; OS: Overall survival; DFS: Disease free survival.