Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma

Figure 3 Cumulative survival curves. Cumulative survival curves were stratified by semaphorin 4D (Sema4D) and hypoxia-inducible factor-1α (HIF-1α) expression in cancer cells. The survival curves were analyzed by Kaplan-Meier analysis and log-rank tests. A: Colorectal carcinoma patients with positive Sema4D expression exhibited shorter overall survival compared with patients with negative expression (P = 0.009); B: Colorectal carcinoma patients with positive HIF-1α expression exhibited shorter overall survival compared with those with negative expression (P = 0.497). Neither value reached statistical significance.