Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma

Figure 1 Hypoxia-inducible factor-1α expression patterns. A: A sample with strong cytoplasmic staining for hypoxia-inducible factor-1α (HIF-1α) in the advancing tumor border is shown; interstitial cells are positive for HIF-1α (× 200); B: Cancer tissue with positive immunostaining for HIF-1α (× 400); C: Cancer tissue with negative immunostaining for HIF-1α (× 200); D: HIF-1α is not expressed in normal tissue (× 200).