ARID1A expression in gastric adenocarcinoma: Clinicopathological significance and correlation with DNA mismatch repair status

Figure 1 Immunohistochemistry for mismatch repair proteins in a case of gastric cancer with a mismatch repair-deficient phenotype. Immunohistochemistry for MLH1 (A), PMS2 (B), MSH2 (C), and MSH6 (D). MLH1 and PMS2 expression are absent in tumor cells, whereas stromal cells show nuclear expression (A, B). On the other hand, the tumor cells retain MSH2 and MSH6 expression (C, D). These staining patterns were consistent with those caused by MLH1 deficiency.