Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma

Table 3 Survival analysis of prognosis factors in colorectal carcinoma

		5-yr survival rate
	n	n (%)	χ2	P value
Age (yr)			1.664	0.197
≤ 50	40	12 (30)
> 50	46	20 (43)
Differentiation			4.7571	0.0291
High	28	15 (54)
Medium	42	13 (31)
Low	16	4 (25)
Tumor size			0.058	0.810
< 5 cm	50	18 (36)
≥ 5 cm	36	14 (39)
TNM stage			5.127	0.024
I-II	30	16
III-IV	56	16
Lymphatic metastasis			7.061	0.008
Yes	58	16 (28)
No	28	16 (57)
HIF-1α			8.920	0.003
Negative	36	20 (56)
Positive	50	12 (24)
Sema4D			11.244	0.001
Negative	34	20 (59)
Positive	52	12 (23)

¹Represent a significant correlation between the differentiation status of the tumor; HIF-1α: Hypoxia-inducible factor-1 alpha; Sema4D: Semaphorin 4D.