Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma

Table 2 Expression of semaphorin 4D and hypoxia-inducible factor-1α and clinicopathological characteristics of colorectal carcinoma patients

		HIF-1α-positive			Sema4D-positive
	n	n (%)	χ2	P value	n (%)	χ2	P value
Age (yr)			0.013	0.911		0.130	0.719
≤ 50	40	23 (58)			25 (63)
> 50	46	27 (59)			27 (59)
Differentiation			8.5791	0.0031		6.6641	0.0101
High	28	10 (36)			11 (39)
Medium	42	30 (71)			28 (67)
Low	16	10 (63)			13 (81)
Tumor size			0.225	0.636		0.624	0.429
< 5 cm	50	28 (56)			32 (64)
≥ 5 cm	36	22 (61)			20(56)
TNM Stage			8.728	0.003		5.657	0.017
I-II	30	11 (37)			13 (43)
III-IV	56	39 (70)			39 (70)
Lymphatic metastasis			8.579	0.003		5.385	0.020
Yes	58	40 (69)			38 (66)
No	28	10 (36)			14 (50)

¹Represent a significant correlation between the differentiation status of the tumor. HIF-1α: Hypoxia-inducible factor-1α; Sema4D: Semaphorin 4D.