Repeat hepatic resection in patients with colorectal liver metastases

Table 2 Cox regression proportional hazard model of disease-free survival in recurrent colorectal liver metastases

Variable	Primary hepatectomy (n = 406)				Secondary hepatectomy (n = 55)
	Univariate analysis	Multivariate analysis1			Univariate analysis	Multivariate analysis1
	P value	HR	95%CI	P value	P value	HR	95%CI	P value
Male sex	0.110				0.260
Age	0.750				0.360
Metachronous	0.002	0.70	0.42-1.16	0.170	0.670
Multiple CRLM	0.067				0.037	2.78	1.33-5.78	0.006
Size of CRLM	0.001	1.15	1.04-1.26	0.006	0.260
Radiofrequency ablation	0.220				0.008	2.84	1.40-5.73	0.004
T4	0.110				0.530
N1 or N2	0.002	1.17	0.70-1.94	0.550	0.310
Low grade cell differentiation2	< 0.001	2.38	1.46-3.88	0.001	0.660
Lymphatic invasion	< 0.001	1.50	1.02-2.20	0.040	0.100
Vascular invasion	< 0.001	1.49	0.99-2.25	0.058	0.670
Perineural invasion	0.001	1.32	0.88-1.99	0.190	0.820
Adjuvant chemotherapy	0.950				0.140

¹Variables that were significant in univariate analysis were verified with a multivariate model;

²Low grade: poorly differentiated or mucinous carcinoma. CRLM: Colorectal liver metastases.