Repeat hepatic resection in patients with colorectal liver metastases

Table 1 Characteristics of patients with colorectal liver metastases n (%)

Variable	Primary hepatectomy (n = 406)	Secondary hepatectomy (n = 55)	P value1
Sex (M/F)	266:140	36:19	0.99
Median age (yr) (range)	59.5 (26-80)	58 (36-80)	0.95
Number of CRLM (median, range)	1 (1-8)	1 (1-4)	0.01
CRLM size (median, range)	2.4 (0.2-7.5)	2.4 (1.0-7.5)	0.85
Liver metastases
Synchronous	279 (69)	39 (71)	0.74
Metachronous	127 (31)	16 (29)
CRLM number
Single	232 (57)	41 (75)	0.014
Multiple	174 (43)	14 (25)
CRLM treatment
Resection	324 (80)	25 (45)	< 0.001
RFA	57 (14)	29 (53)
Both	25 (6)	1 (2)
T stage
T1 T2 T3	364 (90)	47 (85)	0.35
T4	42 (10)	8 (15)
N stage
N0	117 (29)	13 (24)	0.42
N1 or N2	289 (71)	42 (76)
Histological differentiation2
High grade	367 (90)	53 (96)	0.21
Low grade	39 (10)	2 (4)
Lymphatic invasion
(-)	172 (42)	16 (29)	0.02
(+)	129 (32)	26 (47)
Vascular invasion
(-)	168 (41)	29 (53)	0.14
(+)	102 (25)	10 (18)
Perineural invasion
(-)	191 (47)	20 (36)	0.38
(+)	74 (18)	11 (22)
Chemotherapy
Yes	373 (92)	50 (91)	0.79
No	33 (8)	5 (9)

¹χ² test, Fisher’s exact test, or Mann Whitney U test;

²High grade: well or moderately differentiated, Low grade: poorly differentiated or mucinous carcinoma. CRLM: Colorectal liver metastases.