Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B

Table 4 Genotype at ABCC2 and parameters of proximal kidney tubular dysfunction and estimated glomerular filtration rate of 30 patients treated with adefovir dipivoxil n (%)

	Genotype CC or CT	Genotype TT	P value
	(n = 26)	(n = 4)
Serum phosphate (mmol/L)	0.86 ± 0.21	1.00 ± 0.25	NS
TmP/GFR (mmol/L)	0.73 ± 0.28	0.95 ± 0.42	NS
Serum uric acid (umol/L)	267.2 ± 120.3	258.7 ± 26.4	NS
FEUA (%)	16.6 ± 14.6	9.5 ± 1.6	0.025
UBCR (mg/gCr)	996.3 (68.2-14555.9)	201.4 (81.5-497.7)	0.038
Phosphate diabetes	8 (30.8)	1 (25.0)	NS
Renal hypouricemia	10 (38.5)	0	NS
β2-microglobulinuria	14 (53.8)	1 (25.0)	NS
Nondiabetic glucosuria	5 (19.2)	0	NS
Metabolic acidosis	2 (7.7)	0	NS
eGFR (mL/min per 1.73 m2)	62.8 ± 17.6	64.4 ± 2.1	NS

Data are shown as mean ± SD, percentage, or geometric mean ± SD. Overall P values were calculated by unpaired t-test or χ²-test in comparison between ABCC2 -24 genotype CC/CT and genotype TT. TmP/GFR: Tubular maximum for phosphate corrected for glomerular filtration rate; FEUA: Fractional excretion of uric acid; UBCR: Urine β₂-microglobulin-creatinine ratio; eGFR: Estimated glomerular filtration rate; NS: Not significant.