Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B

Table 3 Logistic regression analysis of the kidney tubular dysfunction of patients treated with adefovir dipivoxil

	OR	95%CI	P value
1Model 1
Age at initiation of ADV (per 5 yr)	2.90	1.16-7.24	0.023
Treatment duration of ADV (per year)	2.31	1.20-4.45	0.013
2Model 2
Age at initiation of ADV (per 5 yr)	5.01	1.07-23.38	0.040
Treatment duration of ADV (per year)	3.21	1.20-8.57	0.020

¹Adjusted for body mass index;

²Adjusted for body mass index, gender, the eGFR level at initiation of ADV, and genotyping of ABCC2 -24 C/T. OR, 95%CI, and P value were calculated by logistic regression analysis. ADV: Adefovir dipivoxil; eGFR: Estimated glomerular filtration rate.