Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B

Table 3 Multivariate logistic regression analysis of factors associated with natural tyrosine-methionine-aspartic acid-aspartic acid mutations

	Univariate		Multivariate
	OR (95%CI)	P value	OR (95%CI)	P value
Age (yr) (< 60, ≥ 60)	1.39 (0.57, 3.40)	0.4700	2.02 (0.72, 5.67)	0.1824
Gender (male, female)	1.41 (0.64, 3.12)	0.4850	1.24 (0.33, 4.59)	0.7518
Alcohol (yes, no)	1.75 (0.72, 4.24)	0.4560	1.27 (0.57, 2.85)	0.5608
Family history1 (yes, no)	2.45 (1.15, 5.25)	0.0040	1.77 (0.24, 3.84)	0.3254
Aspartate aminotransferase (IU/L; < 40, ≥ 40)	2.08 (0.91, 4.81)	0.9630	1.22 (0.28, 5.29)	0.7876
Alanine aminotransferase (IU/L; < 40, ≥ 40)	5.44 (1.45, 20.45)	0.0122	2.59 (1.24, 8.44)	0.0734
Alkaline phosphatase (IU/L; < 120, ≥ 120)	2.62 (0.67, 10.23)	0.9520	3.42 (0.81, 14.54)	0.0952
Gamma-glutamyl transpeptidase (IU/L; < 40, ≥ 40)	1.08 (0.47, 2.50)	0.8520	1.18 (0.35, 3.99)	0.7957
HBV genotype (A/B/C/other)	1.17 (0.55, 2.49)	0.3200	1.05 (0.40, 2.77)	0.5246
HBeAg state (+/-)	3.01 (1.37, 6.63)	0.0190	3.56 (1.55, 8.18)	0.0282
HBV DNA (LGE; < 5, ≥ 5)	2.45 (1.15, 5.25)	0.0240	2.70 (1.23, 5.92)	0.0133

HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; LGE: Log10 genome equivalents.