Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3

Figure 4 Overexpression of B7-H3 enhances the anti-apoptotic effect in colorectal cancer cells via the activation of the Jak2-STAT3 pathway. A: Western blot analysis with the control cells (SW620-NC), the B7-H3 overexpressing cells (SW620-B7-H3-EGFP) and the AG490 treated B7-H3 overexpressing cells (SW620-B7-H3-EGFP+AG490) demonstrating the expression of Jak2-STAT3 pathway proteins and apoptosis regulator proteins; B: Comparison of relative protein levels from (A); C: A simple pathway map for B7-H3 regulation of the anti-apoptotic effect in CRC cells. ^aP < 0.05 vs control. CRC: Colorectal cancer; Jak2: Janus kinase 2; NC: Negative control; STAT3: Signal transducer and activator of transcription 3.