Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver

Figure 5 Parenchymal (microdialytic) glycerol (mean ± SE) in the ischemic liver lobes in rats subjected to 45 min of segmental (left lateral lobe) liver ischemia and 4 h of reperfusion with (nitrite, n = 14) or without (ischemia reperfusion injury, n = 14) intravenous pre-treatment with 480 nmol of nitrite and sham operated animals (n = 8). During ischemia, the parenchymal glycerol increased in both groups; during the ischemic phase and the first 30 min of the reperfusion phase, the levels were higher in the untreated group (P = 0.049). The shaded area represents the ischemic phase. IRI: Ischemia reperfusion injury.