Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach

doi:10.3748/wjg.v21.i6.1765

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 6

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9351)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-7) series.

Item

Count

PDF

532

WORD

376

HTML

4477

Figures (1-7)

209

Sum=5594

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

510

Download

948

Sum=1458

Publishing Process of This Article

Item

Count

Browse

1107

Download

1192

Sum=2299

Feb 14, 2015 (publication date) through Nov 26, 2024

Times Cited of This Article

Times Cited (23)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Feb 14, 2015; 21(6): 1765-1774
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1765

Full Size Figure Download Figure

Figure 7 Schematic model of the protective effect of sirtuin 1 against ischemia-reperfusion injury associated to rat orthotopic liver transplantation. Trimetazidine (TMZ) addition to IGL-1 promotes NAMPT expression and enhances NAD+ levels, which in turn provokes SIRT1 up-regulation. SIRT1 contributes to decreased hepatic injury by inhibiting mitochondrial damage and oxidative stress, activating autophagic pathway and by enhancing p-ERK and decreasing p-p38 protein expression. SIRT1: Sirtuin 1; IRI: Ischemia-reperfusion injury; OLT: Orthotopic liver transplantation.

Citation: Pantazi E, Zaouali MA, Bejaoui M, Folch-Puy E, Ben Abdennebi H, Varela AT, Rolo AP, Palmeira CM, Roselló-Catafau J. Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach. World J Gastroenterol 2015; 21(6): 1765-1774
URL: https://www.wjgnet.com/1007-9327/full/v21/i6/1765.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i6.1765