Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach

doi:10.3748/wjg.v21.i6.1765

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Feb 14, 2015 (publication date) through Oct 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2015; 21(6): 1765-1774
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1765

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Figure 7 Schematic model of the protective effect of sirtuin 1 against ischemia-reperfusion injury associated to rat orthotopic liver transplantation. Trimetazidine (TMZ) addition to IGL-1 promotes NAMPT expression and enhances NAD+ levels, which in turn provokes SIRT1 up-regulation. SIRT1 contributes to decreased hepatic injury by inhibiting mitochondrial damage and oxidative stress, activating autophagic pathway and by enhancing p-ERK and decreasing p-p38 protein expression. SIRT1: Sirtuin 1; IRI: Ischemia-reperfusion injury; OLT: Orthotopic liver transplantation.

Citation: Pantazi E, Zaouali MA, Bejaoui M, Folch-Puy E, Ben Abdennebi H, Varela AT, Rolo AP, Palmeira CM, Roselló-Catafau J. Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach. World J Gastroenterol 2015; 21(6): 1765-1774
URL: https://www.wjgnet.com/1007-9327/full/v21/i6/1765.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i6.1765