Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach

Figure 2 NAMPT protein expression (A), NAD⁺/NADH levels (B), SIRT1 (C), ac-FoxO1 (D) and ac-p53 (E) protein expression in livers after 24 h of reperfusion. Sham: Liver harvested without transplantation, IGL-1: Liver transplanted after 8 h of cold storage in IGL-1 solution; IGL-1 + TMZ: Liver transplanted after 8 h of cold storage in IGL-1 solution with 10^-6 mol/L trimetazidine (TMZ). ^aP < 0.05 vs Sham; ^cP < 0.05 vs IGL-1. NAMPT: Nicotinamide phosphoribosyltransferase; NAD⁺: Nicotinamide adenine dinucleotide; SIRT1: Sirtuin 1; FoxO1: Forkhead box-containing protein O 1; NADH: Nicotinamide adenine dinucleotide.