Management of patients with hepatitis B in special populations

Table 2 Dosage adjustment of nucleos(t)ides analogs in patients with chronic hepatitis B according to the creatinine (CrCl)[44]

CrCl (mL/min)	Lamivudine	Telbivudine	Adefovir	Entecavir1	Tenofovir
≥ 50	100 mg/d	600 mg/d	10 mg/d	0.5 mg/d	245 mg/d
30-49	50 mg/d	600 mg/2nd day	10 mg/2nd day	0.25 mg/d	245 mg/2nd day
10-29	25 mg/d	600 mg/3rd day	10 mg/3rd day	0.15 mg/d	245 mg/3rd-4th day
< 5-10 or HD2	10 mg/d	600 mg/3rd-4th day	10 mg/wk	0.5 mg/wk	245 mg/wk3

¹Recommendations only for nucleos(t)ide analog naïve patients (in lamivudine resistance the dosage is double);

²In patients undergoing HD, all agents should be given once weekly after an HD session;

³Only for patients on HD. HD: Hemodialysis.