Biological therapy in inflammatory bowel diseases: Access in Central and Eastern Europe

Table 1 Incidence and prevalence of Crohn's disease and ulcerative colitis in the total population in 9 selected Central and Eastern European countries

Ref.	Country, region/city	Study period	Incidence/105		Prevalence/105
			CD	UC	CD	UC
Burisch et al[8], 20141	Czech Republic, Prague	2010	5.50	5.5	-	-
	South Bohemia		3.80	3.8
Bitter and Hulec[45], 1980	Czech Republic, North Bohemia	1968-1978	-	1.3	-	17.6
Nedbal et al[46], 1967	Czech Republic	1960-1965	-	1.4	-	10.7
Salupere[47], 2001	Estonia, Tartu County	1993-1998	1.40	1.7	-	-
Kull et al[48], 1998	Estonia, Tartu County	1973-1992	0.27	1.5	-	-
Burisch et al[8], 20141	Estonia, Southern Estonia	2010	5.20	5.2	-	-
Nagy et al[49], 2004	Hungary, Borsod-Abaúj-Zemplén County	1962-1992	-	1.4	-	10.4
Lakatos et al[10], 2011	Hungary, Western Hungary	2002-2006	8.87	11.9	115.3	211.1
Lakatos et al[9], 2004	Hungary, Veszprém County	I: 1997-2001	2.23	5.89	52.9	142.6
		P: 1991-2001
Burisch et al[8], 20141	Hungary, Veszprém County	2010	11.5	10.3	-	-
Zvirbliene et al[50], 20032	Lithuania	1995-2001	-	-	10.0	30-40
Kiudelis et al[51], 2012	Lithuania, Kaunas	2007-2009	1.21	6.56	-	-
Burisch et al[8], 20141	Lithuania, Kaunas	2010	2.40	6.1	-	-
Chojecki[52], 1964	Poland, Warsaw	1951-1960	0.66	-	66.0	-
Wiercinska-Drapalo et al[53], 2005	Poland, Bialystok	1990-2003	0.10	1.8	-	-
Gheorghe et al[54], 1997	Romania, Bucharest	1990-1997	0.42	-	-	-
Gheorghe et al[11], 2004	Romania, nationwide	I: 2002-2003	0.50	0.97	1.51	2.42
		P: 2004
Toader[55], 2008	Romania, North-East region	1988-2007	1.54	0.35	-	-
Burisch et al[8], 20141	Romania, Timis	2010	1.70	2.4	-	-
Príkazská et al[56], 1996	Slovakia, nationwide	1994	6.75	-	-	-
Príkazka et al[57], 1998	Slovakia, nationwide	1994	-	-	6.75	-
Gregus et al[12], 2014	Slovakia	2013	4.60	6.8	80.5	150.5

¹Aged ≥ 15 years;

²Extrapolation by Lakatos et al[7], 2006. I: Incidence; P: Prevalence; CD: Crohn's disease; UC: Ulcerative colitis.