KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients

Figure 2 Sequence chromatograms displaying concomitant mutations of KRAS and BRAF found in this study. Concomitant mutations of KRAS G12V (A) and BRAF R603stop were detected in colorectal carcinoma tissue of a 71-year-old woman (B). Another patient, a 62-year-old woman, had mutations of both KRAS G13D (C) and BRAF S602Y (D). The amino acid changes corresponding to the codon alternations are as follows: G12V (GGT→GTT) and G13D (GGC→GAC) in exon 2 of the KRAS gene, S602Y (TCT→TAT) and R603stop (CGA→TGA) in exon 15 of the BRAF gene.