Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

Figure 2 Proportions of T helper 22, T helper 17 and T helper 1 cells were significantly increased in mice with hepatic fibrosis. A-C: Representative images of T helper (Th)-22, Th17 and Th1 cells in the fibrosis group and the control group; D-F: The results of statistical analyses for the alterations in Th22, Th17 and Th1 cells in different subgroups; G-I: Correlation analyses of Th22 and Th17 cells, Th22 and Th1 cells, Th17 and Th1 cells in the fibrosis group at week 4. ^bP < 0.01 vs control subgroups sacrificed at the same time point; ^dP < 0.01 vs the other fibrosis subgroups. Data are mean ± SD (n = 8-10). ILs: Interleukins; IFN: Interferon.