Mechanism involved in Danshen-induced fluid secretion in salivary glands

Figure 6 Inactivation of NKCC1 by bumetanide. A: The effects of bumetanide on Danshen-induced salivary fluid secretion. Initially, CCh was added for 5 min as a control measure. At 20 min bumetanide was added for 5 min, and the fluid secretion decreased significantly to a plateau inhibited level (P < 0.05 vs control). This figure shows the average values (bold line, n = 6) and the standard error of the means (mean ± SE, dotted lines); B. The effects of bumetanide on DS-induced oxygen consumption. The oxygen consumption was shown by arterio-venous difference of partial oxygen pressure (mmHg). Initially, CCh was added for 5 min as a control measure. At 20 min bumetanide was added for 5 min. DS: Danshen; CCh: Carbamylcholine.