HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis

Table 3 Meta-analysis results of -1790G>A polymorphism

	Dominant comparison		Allele comparison		Heterozygote comparison
	OR (95%CI)	Phet	OR (95%CI)	Phet	OR (95%CI)	Phet
Overall	3.252 (1.661-6.368)1	< 0.001	4.455 (1.938-10.241)1	< 0.001	2.677 (1.677-4.273)1	< 0.001
Ethnicity
Caucasian	1.882 (0.627-5.644)	< 0.001	2.881 (0.943-8.807)	0.009	1.898 (0.411-8.761)	0.002
Asian	2.921 (1.909-4.470)1	0.163	2.793 (1.877-4.158)1	0.195	2.891 (1.890-4.422)1	0.165
Source of control
HB	3.258 (1.331-7.977)1	< 0.001	4.904 (1.375-17.489)1	< 0.001	2.521 (1.526-4.167)1	0.094
PB	3.516 (1.340-9.229)1	0.026	3.923 (1.894-8.128)1	0.084	2.729 (0.823-9.053)1	0.011
Cancer types
OC	7.919 (1.582-39.636)1	< 0.001	9.663 (1.312-71.149)1	< 0.001	3.165 (1.264-7.924)1	0.019
PC	2.499 (0.929-6.726)	0.098	3.030 (1.946-4.716)1	0.418	1.611 (0.241-10.760)	0.019
CRC	0.971 (0.571-1.650)	0.454
Sample size
Small	4.127 (1.511-11.267)1	< 0.001	4.976 (1.457-16.996)1	< 0.001	2.351 (1.180-4.682)1	0.007
Large	2.186 (0.863-5.537)	0.001	3.313 (2.214-4.959)1	0.969	3.492 (2.298-5.307)1	0.690

¹Significant association. OR: Odds ratio.