KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients

doi:10.3748/wjg.v21.i5.1595

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2015; 21(5): 1595-1605
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1595

Table 5 Correlations between DNA mismatch repair protein deficiency and clinicopathological features n (%)

Clinicopathological feature		dMMR		MLH1/PMS2		MSH2/MSH6
Clinicopathological feature		Defective/tested	P value	Defective/tested	P value	Defective/tested	P value
Total		55/481 (11.4)		31/481 (6.4)		24/481 (5.0)
Gender	Male	25/272 (9.2)	0.095	12/272 (4.4)	0.034	13/272 (4.8)	0.970
Gender	Female	29/206 (14.1)	0.095	19/206 (9.2)	0.034	10/206 (4.9)	0.970
Age (yr)	< 50	9/50 (18.0)	0.114	3/50 (6.0))	1.000	6/50 (12.0)	0.031
Age (yr)	≥ 50	45/428 (10.5)	0.114	28/428 (6.5)	1.000	17/428 (4.0)	0.031
Location	Right colon	33/161 (20.5)	0.000	23/161 (14.3)	0.000	10/161 (6.2)	0.446
	Left colon	13/142 (9.2)		5/142 (3.5)	0.000	8/142 (5.6)
	Rectum	9/178 (5.1)		3/178 (1.7)		6/178 (3.4)
Mucin production	With	20/99 (20.2)	0.002	11/99 (11.1)	0.034	9/99 (9.1)	0.065
Mucin production	Without	35/382 (9.2)	0.002	20/382 (5.2)	0.034	15/382 (3.9)	0.065
Tumor differentiation	Poor	13/79 (16.5)	0.125	6/79 (7.6)	0.649	7/79 (8.9)	0.148
Tumor differentiation	Well-moderate	42/402 (10.4)	0.125	25/402 (6.2)	0.649	17/402 (4.2)	0.148
Tumor stage	I-II	37/246 (15.0)	0.012	20/246 (8.1)	0.127	17/246 (6.9)	0.049
Tumor stage	III-IV	18/234 (7.7)	0.012	11/234 (4.7)	0.127	7/234 (3.0)	0.049

Citation: Ye JX, Liu Y, Qin Y, Zhong HH, Yi WN, Shi XY. KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients. World J Gastroenterol 2015; 21(5): 1595-1605
URL: https://www.wjgnet.com/1007-9327/full/v21/i5/1595.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i5.1595