Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells

Figure 2 Effects of fenugreek lactone on palmitate-induced lipid accumulation in NIT-1 pancreatic β-cells. A-C: Oil Red O staining of lipid droplets showed that palmitate (PA) induced a palpable increase in lipid accumulation, which was inhibited by the fenugreek lactone (FL) treatment (A: Control group; B: PA group; and C: FL-treated group); D: Intracellular triglyceride (TG) content extracted from NIT-1 cells. FL decreased intracellular TG content in NIT-1 pancreatic β-cells compared with PA group. CON refers to control group, PA refers to palmitic acid intervention group and FL refers to FL-treated group. Data are reported as the mean ± SD (n = 4). ^bP < 0.01 vs control group; ^dP < 0.01 vs PA group.