Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice

Figure 1 Protein kinase C-δ expression and activation (Thr⁵⁰⁵ phosphorylation) in liver tissue and peripheral blood mononuclear cells of mice with D-galactosamine/lipopolysaccharide-induced acute liver failure. Acute liver failure was induced in BALB/c mice using D-galactosamine (600 mg/kg) and lipopolysaccharide (10 μg/kg). A: PKC-δ expression and Thr⁵⁰⁵ phosphorylation in liver tissue; B: PKC-δ expression and Thr⁵⁰⁵ phosphorylation in peripheral blood mononuclear cells. PKC: Protein kinase C.