Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway

Figure 1 Human L-02 and HepG2 cells show different cell viabilities in response to guggulsterone treatment. Cell viability in L-02 and HepG2 cells was determined using MTT assay after incubation with 5, 10, 25, 50, 75 and 100 μmol/L guggulsterone, respectively, for 24 h. Guggulsterone significantly reduced cell viability in both L-02 and HepG2 cells in a dose- and time-dependent manner (A). Same concentration of guggulsterone differently reduced cytotoxicity between L-02 and HepG2 cells (B). ^aP < 0.05 or ^bP < 0.01, vs the control group.