Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan

Table 1 Patient demographic and clinical characteristics n (%)

Clinical parameters	United Kingdom (n = 126)	Japan (n = 126)	Total (n = 252)	P value (United Kingdom vs Japan)
Sex
Male	63 (50.0)	44 (35.0)	107 (42.5)	0.019
Female	63 (50.0)	82 (65.0)	145 (57.5)
Age (yr)
≥ 50	63 (50.0)	65 (51.6)	128 (50.8)	0.801
< 50	63 (50.0)	61 (48.4)	124 (49.2)
Helicobacter pylori IgG
Positive	47 (37.3)	56 (44.4)	103 (40.9)	0.733
Negative	79 (62.7)	70 (55.6)	149 (59.1)
Serologic features (ng/mL), mean ± SD
Pepsinogen I	51.9 ± 40.0	50.7 ± 26.8	51.3 ± 33.8	0.780
Pepsinogen II	13.0 ± 8.9	13.7 ± 9.7	13.4 ± 9.3	0.552
Pepsinogen I/II ratio	4.4 ± 1.8	4.6 ± 2.2	4.5 ± 2.0	0.364
Histological atrophy
None	56 (44.4)	38 (30.2)	94 (37.3)	< 0.001
Antrum	49 (38.8)	19 (15.0)	68 (27.0)
Angulus	19 (15.0)	20 (15.8)	39 (15.5)
Lesser curvature of middle body	2 (1.6)	25 (19.8)	27 (10.7)
Greater curvature of middle body	0 (0)	24 (19.0)	24 (9.5)
Endoscopic atrophy
No atrophy	56 (44.4)	27 (21.4)	83 (32.9)	< 0.001
Antral (C-1)	40 (31.8)	33 (26.2)	73 (29.0)
Antral predominant (C-2)	24 (19.0)	20 (15.8)	44 (17.5)
Corpus predominant (C-3-O-2)	6 (4.8)	43 (34.2)	49 (19.4)
Pan-atrophy (O-3)	0 (0)	3 (2.4)	3 (1.2)