Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

doi:10.3748/wjg.v21.i46.13064

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2015; 21(46): 13064-13072
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13064

Table 7 TNF-α genotypes and survival in Okuda stage III hepatocellular carcinoma cases

Genotype	Validation set		Adjusted HR (95%CI)¹	P-value
Genotype	Cases (n = 43)	Deaths (n = 41)	Adjusted HR (95%CI)¹	P-value
TNF-α -1031 T>C, rs1799964
TT	29 (67.4)	27 (65.9)	1.000 (reference)
TC	11 (25.6)	11 (26.8)	1.314 (0.448-3.856)	0.621
CC	3 (7.0)	3 (7.3)	5.795 (1.145-29.323)	0.035
Dorminant model (TT vs TC + CC)			1.805 (0.733-4.442)	0.201
Recessive model (TT + TC vs CC)			3.761 (0.869-16.265)	0.078

¹Adjusted for age, sex, hypertension, diabetes mellitus, drinking status, smoking status, portal vein thrombosis, tumor size, surgical resection, and chemotherapy or radiotherapy.

Citation: Shin SP, Kim NK, Kim JH, Lee JH, Kim JO, Cho SH, Park H, Kim MN, Rim KS, Hwang SG. Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea. World J Gastroenterol 2015; 21(46): 13064-13072
URL: https://www.wjgnet.com/1007-9327/full/v21/i46/13064.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i46.13064