Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

Table 4 TNF-α genotype combinations in hepatocellular carcinoma cases and controls¹n (%)

Genotype	HCC cases, n = 157	Controls, n = 201	AOR (95%CI)2	P-value
TNF-α -1031/-857/-238
TT/CC/GG	56 (35.7)	81 (40.3)	1.000 (reference)
TT/CC/GA	11 (7.0)	2 (1.0)	18.849 (2.203-161.246)	0.007
TNF-α -1031/-308/-238
TT/GG/GG	68 (43.3)	103 (51.2)	1.000 (reference)
TT/GG/GA	13 (8.3)	2 (1.0)	26.956 (3.071-236.584)	0.003
TT/GA/GG	17 (10.8)	14 (7.0)	2.712 (1.085-6.778)	0.033
TNF-α -863/-308/-238
CC/GG/GG	68 (43.3)	99 (49.3)	1.000 (reference)
CC/GA/GG	16 (10.2)	13 (6.5)	2.533 (1.007-6.371)	0.048
CA/GG/GA	13 (8.3)	5 (2.5)	4.242 (1.243-14.473)	0.021
TNF-α -1031/-238
TT/GG	86 (54.8)	119 (59.2)	1.000 (reference)
TT/GA	13 (8.3)	2 (1.0)	21.576 (2.581-180.394)	0.005
TNF-α -863/-238
CC/GG	85 (54.1)	114 (56.7)	1.000 (reference)
CA/GA	13 (8.3)	5 (2.5)	3.669 (1.098-12.253)	0.035
TNF-α -308/-238
GG/GG	107 (68.2)	160 (79.6)	1.000 (reference)
GA/GG	23 (14.6)	18 (9.0)	2.283 (1.078-4.836)	0.031
GA+AA/GG	24 (15.3)	20 (10.0)	2.150 (1.041-4.441)	0.039

¹Only combinations significantly associated with HCC are presented in the table;

²Adjusted for age, sex, hypertension, diabetes mellitus, drinking status, and smoking status. HCC: Hepatocellular carcinoma.