Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy

Figure 7 Heat shock pretreatment improves the therapeutic potential of mesenchymal stem cells in the treatment of hepatic ischemia-reperfusion injury in vivo. A: Serum aminotransferase levels were measured using an automatic analyzer following treatment; B: Histopathological analyses of livers from the normal control, I/R-control, mesenchymal stem cells (MSCs) and HSP-MSC groups. Liver tissue sections were stained with HE and scored according to the Suzuki Scoring System. Original magnification, × 100 and × 400, respectively, for each slide; C: Expression of PCNA by immunohistochemistry in liver tissues (magnification × 100 and × 400). The arrows indicate positive stained cells by PCNA. The data represent the results of three separate experiments. ^bP < 0.01 compared with the normal control group; ^dP < 0.01 compared with the I/R control group; ^cP < 0.05 compared with the MSC group.