Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

Figure 6 Effects of GW501516 on lipid peroxidation and associated molecular pattern-activated protein kinase-α phosphorylation in mice fed a high fat diet. Liver malondialdehyde (MDA) levels (A) showed a slight increase in the HFD + lipopolysaccharide (LPS) group without statistical significance; B: Representative immunoblot and graphic presentation of p-AMPK-α and total AMPK-α protein levels in the livers of mice are shown. Treatment of GW501516 enhanced phosphorylation of AMPK-α in mice fed an HFD with LPS injection. Data are expressed as the mean ± SD (5-6 mice per group).