Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

Figure 5 Histopathological features of livers in mice fed a high fat diet with or without lipopolysaccharide injection and GW501516 treatment. A: Hematoxylin and eosin (HE) staining and Oil Red O staining of hepatic lipid accumulation (magnification × 100). In mice fed an HFD, moderate macrovesicular steatosis (17.0%) and inflammatory cell infiltration were observed compared with the control group. The macrovesicular steatosis was improved to 2.7% following GW501516 treatment; B: Histogram of the percentage of hepatocytes showing macrovesicular fatty change; C: Nonalcoholic fatty liver disease (NAFLD) activity score. The NAFLD activity score in the GW501516-treated group was significantly lower than that in the HFD + LPS group (1.8 vs 0.5, P < 0.05). Data are expressed as the mean ± standard deviation (SD) (5-6 mice per group). ^aP < 0.05, ^bP < 0.01, and ^dP < 0.001 vs control group. ^cP < 0.05 vs the HFD + LPS group.