Copyright
©The Author(s) 2015.
World J Gastroenterol. Nov 28, 2015; 21(44): 12519-12543
Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12519
Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12519
Figure 2 Mesalazine mode of action.
Antigen presenting cells (APCs) recognize luminal antigens penetrating the colonic wall and through interaction with Th1 cells induce the production of interferon (IFN)-γ. IFN-γ activates epithelial cells. 5-aminosalicylic acid (5-ASA) is able to block transcription of inflammatory cytokines in colonic epithelial cells. IL: Interleukin; TNF: Tumor necrosis factor.
- Citation: Quetglas EG, Mujagic Z, Wigge S, Keszthelyi D, Wachten S, Masclee A, Reinisch W. Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease. World J Gastroenterol 2015; 21(44): 12519-12543
- URL: https://www.wjgnet.com/1007-9327/full/v21/i44/12519.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i44.12519