Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects

Figure 3 Effects of intake of broccoli sprout extract on liver function markers in serum from N-nitrosodimethylamine-induced chronic liver failure model rats. A, B: Serum activities of aspartate-aminotransferases (AST) and alanine aminotransferase (ALT) in male Sprague-Dawley rats who had received an AIN-76 diet containing no (sham, n = 6 and control, n = 8) or different amounts of BS extract at glucoraphanin (GR) doses of 62.5, 125, and 250 mg per 100 g diet (BS-low, BS-middle, and BS-high, respectively, n = 8) for 4 wk. All rats, except for the sham group, were intraperitoneally injected with N-nitrosodimethylamine (5 mg per kg body weight) on 3 consecutive days of the week for 4 wk; C, D: Serum levels of albumin and bilirubin in the rats. Data are shown as boxplots representing the minimum (bottom of the bar), 25th percentile (bottom of the box), median (horizontal line), 75^th percentile (top of the box), and the maximum observations (top of the bar). ^aP < 0.05 vs sham; ^cP < 0.05, ^dP < 0.01 vs control (Steel-Dwass test). BS: Broccoli sprout.