Relationship between virological response and FIB-4 index in chronic hepatitis B patients with entecavir therapy

Table 4 Multivariate analysis of factors predicting maintained viral suppression in relation to virological response at week 48 using the Cox proportional hazard model in hepatitis B e antigen-positive patients

	Maintained viral suppression at week 144
	HR	95%CI	P value
Age (yr)	1.008	0.98-1.04	0.54
Sex	0.927	0.694-1.325	0.68
ALT (IU/L)	1.000	0.997-1.004	0.81
AST (IU/L)	1.001	0.994-1.000	0.77
PLT (× 109/L )	0.998	0.994-1.000	0.40
HBeAg-positive	1.326	0.918-1.916	0.13
Baseline HBV DNA	0.781	0.678-0.900	< 0.001
(log10 IU/mL)
HBV DNA at week 48	0.768	0.694-0.993	< 0.001
(log10 IU/mL)
FIB-4 index	0.737	0.452-1.199	0.22

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen.