Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients

Table 1 Baseline characteristics of patients

Variable		n	%
Clinicopathological factors
Age (yr)	< 65/≥ 65	123/54	69.5%/30.5%
Sex	Male/female	83/94	46.9%/53.1%
ECOG-PS	0-1/2-4	105/72	59.3%/40.7%
Tumor site	Colon/rectum	125/52	70.6%/29.4%
Liver metastasis	No/yes	69/108	39.0%/61.0%
Prior surgery	No/yes	33/144	18.6%/81.4%
Prior chemotherapy	None/1st line/2nd line/≥ 3rd line	21/28/54/74	11.9%/15.8%/30.5%/41.8%
Prior radiotherapy	No/yes	126/51	71.2%/28.8%
BMI (kg/m2)	< 18.5/18.5-22.9/≥ 23	22/88/64	12.6%/50.6%/36.8%
KM treatment duration (mo)	< 2.9/≥ 2.9	89/88	50.3%/49.7%
Laboratory factors
CEA (ng/mL)	≤ 5/> 5	31/140	18.1%/81.9%
CA19-9 (U/mL)	≤ 27/> 27	59/78	43.1%/56.9%
Hb (g/dL)	> 12.1/ ≤ 12.1	95/82	53.7%/46.3%
AST (IU/L)	< 40/≥ 40	147/30	83.1%/16.9%
ALT (IU/L)	< 40/≥ 40	157/20	88.7%/11.3%
eGFR (mL/min)	≥ 60/< 60	139/36	79.4%/20.6%
albumin (g/dL)	< 3.5/≥ 3.5	13/164	7.3%/92.7%
CRP (mg/L)	< 10.0/≥ 10.0	114/63	64.4%/35.6%
PLT (× 103/μL)	< 400/≥ 400	161/16	62.7%/37.3%
WBC (× 103/μL)	< 10.0/≥ 10.0	161/16	91.0%/9.0%
Neutrophil (%)	≤ 68.2/> 68.2	92/85	52.0%/48.0%
Lymphocyte (%)	≤ 24.3/> 24.3	111/66	62.7%/37.3%
Monocyte (%)	≤ 6.6/> 6.6	59/118	33.3%/66.7%
ANC (cells/μL)	≤ 4505.7/> 4505.7	104/73	58.8%/41.2%
ALC (cells/μL)	≤ 1651.3/> 1651.3	123/54	69.5%/30.5%
AMC (cells/μL)	≤ 460.8/> 460.8	83/94	46.9%/53.1%
mGPS	0/1/2	114/52/11	64.4%/29.4%/6.2%
NLR	< 5/≥ 5	144/33	81.4%/18.6%
PLR	< 150/150-300/> 300	73/78/26	41.2%/44.1%/14.7%
LMR	≤ 3.4/> 3.4	113/64	63.8%/36.1%
PNI	≤ 45.3/> 45.3	52/125	29.4%/70.6%

ECOG-PS: Eastern cooperative oncology group performance status; BMI: Body mass index; KM: Korean Medicine; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; Hb: Hemoglobin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; eGFR: Estimated glomerular filtration rate; CRP: C-reactive protein; PLT: Platelet; WBC: White blood cell; ANC: Absolute neutrophil count; ALC: Absolute lymphocyte count; AMC: Absolute monocyte count; mGPS: Modified Glasgow prognostic score; NLR: Neutrophil to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; LMR: Lymphocyte to monocyte ratio, PNI: Prognostic nutritional index.