Th17 plasticity and its changes associated with inflammatory bowel disease

Table 1 Cytokines related to 17 secreting helper T development and plasticity in human

Cytokine	Effect	Ref.
IL-1β	Accelerate IL-17A secretion from IL-17 secreting Innate	[69]
	Lymphoid cells and Th17
IL-6	Induce autocrine IL-21 and generation of Th17	[20]
IL-10	Suppress IL-17A and Th17 generation	[62]
IL-12	Induce IFN-γ secretion from Th17 cells (Th1/Th17 plasticity)	[20]
IL-21	Potentiates pathogenic effects of Th17 cells in the gut	[64,65]
IL-22	Attenuate the development of intestinal pathology via Stat3-mediated effects on epithelial cells	[66,67]
IL-23	Induce IL-22 and IL-17A secretions and maintain Th17 expansion	[68]
TGF-β1	Initiate generation of Treg and Th17 populations dependent on the concentration	[63]

Th17: 17 secreting helper T; IL: Interleukin; TGF: Transforming growth factor; IFN: Interferon.