MicroRNA in inflammatory bowel disease: Translational research and clinical implication

Table 2 Aberrant microRNA expression in human colonic tissue in Crohn’s disease

Status	Tissue type	Control	Aberrant microRNA expression	Ref.
Active CD	Sigmoid, n = 5	Healthy	Decreased: miR-19b and 629	Wu et al[26], 2010
			Increased: miR-23b, 106a and 191
	Terminal ileum, n = 6	Healthy	Increased: miR-16, 21, 223, and 594	Wu et al[26], 2010
	Colon, nonspecific, n = 16	Healthy	Increased: miR-9, 21, 22, 26a, 29b, 29c, 30b, 31, 34c-5p, 106a, 126, 126*, 127-3p, 130a, 133b, 146a, 146b-5p, 150, 155, 181c, 196a, 324-3p and 375	Fasseu et al[19], 2010
	Colon, nonspecific, n = 8	Healthy	Decreased: miR-7	Nguyen et al[27], 2010
	Colon, nonspecific, n = 120	Healthy	Increased: miR-196	Brest et al[28], 2011
Active and inactive CD	Colon, nonspecific, n = 15	Healthy	Increased: miR-31 and 141	Huang et al[29], 2015
	Colon, distalmost, n = 9	Healthy	Decreased: miR-194b, 216b, 548e and 559 Increased: miR-31, 146a, 206 and 663	Lin et al[23], 2014
Inactive CD	Colon, nonspecific, n = 8	Healthy	Increased: miR-9*, 21, 22, 26a, 29b, 29c, 30a*, 30b, 30c, 31, 34c-5p, 106a, 126*, 127-3p, 133b, 146a, 146b-5p, 150, 155, 196a, 223 and 324-3p	Fasseu et al[19], 2010
Active CD	Colon, left or sigmoid, n = 9	Inactive CD	Decreased: miR-18a*, 140-3p, 629* and let-7b Increased: miR-328, 422a and 885-5p	Iborra et al[25], 2013

CD: Crohn’s disease; UC: Ulcerative colitis.