Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Table 1 Role of Akt in regulating cell cycle

Cell cycle regulation by Akt upon mitogen stimulation
Cell cycle phase	Direct regulation	Indirect regulation	Downstream effect
G1 → S phase	P-p21 at Thr145 residue[107]	↑ Transcription of c-MYC[108]	Increase in CyclinD expression
			Decrease in cdk inhibitors: p21cip1, p21kip1, p15INK4B
G2 → M phase	P-Cdc25B at Ser353[109]		Cdc-25B inactivation
			Cyclin B activation
	P-Wee1Hu at Ser642[110]		Inactivation of Wee1Hu results in G2/M cell cycle progression
	P-Myt1 at Ser75[111]		Activation of Cyclin B-associated Cdk1 kinase activity
S → G2 phase	P-Cdk2 at Thr39[112]		Cytoplasmic shuttling of Cdk2