Stage migration vs immunology: The lymph node count story in colon cancer

Table 4 Prognostic relevance of lymph node harvest in stage II colorectal cancers

First author	Year	n	Insuff rate	pT3/4	Prognostic	Endpoint	Cut off	Survival
Cserni	2002	8574	NA	100%	Yes	OS	No cut off	Continuously improved survival
Cianchi	2002	140	min 40%1	n.m.	Yes	5yOS	≥ 9	54.9% vs 79.9%, P < 0.001
Wong	2002	345	NA	NA	≥ 68	DFS	22.6 vs 11.32	40% vs 90%1, P < 0.001
Berberoglu	2004	301	53.5%1	69%	Yes	5yOS	≤ 10	RR = 2.8 (CI: 1.6-5.2), P = 0.0008
Yoshimatsu	2005	94	35%	100%	Yes	5yOS	≥ 9	66.7% vs 86.7%
Tsai	2007	180	NA	70%	Yes	OS	≥ 18	5yOS: 70 vs 98%1, P = 0.015
Norwood	2009	2449	NA	NA	Yes	OS	< 12	about 15% difference1, P = 0.001
Ishizuka	2010	205	min 36%1	100%	Yes	CsS	≤ 9 vs > 9	44.5 mo vs 66 mo, P = 0.0042
Nir	2010	117	28%	100%	No	5yOS, 5yDFS	≥ 12	No difference
La Torre	2012	204	16%	100%	Yes	5yDFS, 5yCsS, and 5yOS	> 12	5yOS 78.5% vs 53.1%, P = 0.001
Iachetta	2013	657	22%	100%	Yes	CsS/PFS	< 12 vs≥ 20	HR = 0.49 (CI: 0.30-0.79), P = 0.003
Xingmao	2013	729	NA	100%	Yes	OS	> 12	88.7% vs 64.9%, P = 0.000

¹Estimated based on Kaplan-Meier-curve;

²Comparision of different cohorts. NA: No available data; 5yOS: 5 year overall survival; 5yDFS: 5 year disease-free survival; OS: Overall survival; CsS: Cancer specific survival; HR: Hazard rate; LN: Lymph node; PFS: Progression-free survival.