Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

Figure 5 Word cloud of frequent CIS genes from three separate studies using SB transposon forward genetic screening with different genetic backgrounds[63,65,67]. The roles of these frequent CIS gene human orthologs were analyzed using TCGA database. The font size indicates the frequency of genetic alteration reported in human HCC samples. Color of the font indicates the copy number change or expression profile of the gene: red, amplification; blue, deletion; tomato, tends to upregulation; purple, tends to downregulation; yellow, frequently found in all three studies.