Copyright
©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 12114-12124
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12114
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12114
Figure 2 Time-course of matrix metalloproteinase expression following ischemia/reperfusion injury.
In response to injury, pro-inflammatory cytokines, which promptly increase, induce expression of matrix metalloproteinases (MMPs) expression by hepatic cells including hepatic stellate cells (HSCs). The MMPs secreted by HSCs degrade the normal extracellular matrix (ECM) in the space of Disse.
- Citation: Palladini G, Ferrigno A, Richelmi P, Perlini S, Vairetti M. Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review. World J Gastroenterol 2015; 21(42): 12114-12124
- URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12114.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12114