Hepatocellular carcinoma in the elderly: Meta-analysis and systematic literature review

Table 1 Prevalence of viral hepatitis among included studies

Study	Treatment	HBsAg positive (P = 0.023)		HCV Ab positive (P = 0.1681)
		Young	Elderly	Young	Elderly
Yau et al[27]	SR/RFA/TACE	86.00%	52.00%	NA	NA
Chen et al[7]	SR	58.50%	28.60%	NA	NA
Hanazaki et al[8]	SR	23.70%	18.40%	40.70%	55.40%
Yeh et al[9]	SR	74.00%	25.80%	31.80%	63.20%
Ferrero et al[10]	SR	21.40%	10.90%	38.90%	60.90%
Kaibori et al[11]	SR	20.10%	9.70%	69.40%	71.60%
Oishi et al[4]	SR	23.70%	1.56%	66.00%	70.00%
Huang et al[12]	SR	88.80%	65.70%	1.10%	7.50%
Mirici-Cappa et al[13]	SR	15.00%	7.10%	47.10%	57.10%
Tsujita et al[14]	SR	23.00%	8.70%	70.60%	87.00%
Yamada et al[15]	SR	27.30%	36.30%	57.70%	54.50%
Nishikawa et al[16]	SR	17.50%	4.35%	56.30%	66.30%
Hirokawa et al[17]	SR	NA	NA	68.00%	50.00%
Ide et al[18]	SR	21.90%	12.50%	65.10%	68.80%
Liu et al[20]	SR	68.00%	33.00%	23.00%	36.00%
Kishida et al[21]	SR	31.00%	5.00%	43.00%	55.00%
Kim et al[22]	SR	64.50%	28.80%	7.80%	18.60%
Takahashi et al[24]	RFA	1.00%	6.80%	82.70%	93.40%
Mirici-Cappa et al[13]	RFA	13.00%	5.60%	52.20%	74.40%
Nishikawa et al[25]	RFA	11.30%	1.54%	73.90%	86.90%
Liu et al[20]	RFA	48.00%	43.00%	43.00%	39.00%
Fujiwara et al[26]	RFA	13.50%	3.70%	70.40%	79.60%
Yau et al[27]	TACE	87.00%	63.00%	10.00%	18.00%
Mirici-Cappa et al[13]	TACE	11.30%	12.10%	51.70%	59.90%
Liu et al[20]	TACE	52.00%	37.00%	35.00%	35.00%
Nishikawa et al[28]	TACE	15.50%	0.00%	58.30%	71.20%

TACE: Transarterial chemoembolization; RFA: Radiofrequency ablation; NA: Not available; HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus.