Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review

Table 3 Endogenous factors associated with matrix metalloproteinase modulation

Factors	MMPs Involved	I/R Model	Ref.
FN-α-β1	MMP-9MT1-MMP/MMP-14	Cold ischemia	Duarte et al[91], Am J Transpl 2012
			Coito[48], Curr Opin Organ Transplant 2011
			Moore et al[29], Am J Pathol 2007
			Fondevilla et al[95], Transplant Proc 2005
			Amersi et al[47], Am J Pathol 2003
Tenascin-C	MMP-9	Warm ischemia	Kuriyama et al[96], Hepatology 2011
iNOS	MMP-9	Warm ischemia	Hamada et al[46], Am J Pathol 2009
TNF-α	MMP-2 and MMP-9	Warm ischemia	Feng et al[39], J Surg Res 2013
			Palladini et al[43], Toxicol and Pathol 2012
			Khandoga et al[26], J Leukoc Biol 2006
			Chen et al[93], Transplant Proc 2005
IL-1β	MMP-2 and MMP-9	Warm ischemia	Shirahane et al[33], Surgery 2006
IL-6	MMP-9	Warm ischemia	Hamada et al[46], Am J Pathol 2009
IFNα-2a	MMP-2 and MMP-9	Cholestasis	Bueno et al[54], J Hepatol 2000
CD62	MMP-2 and MMP-9	Warm ischemia	Khandoga et al[26], J Leukoc Biol 2006
Plasmin	MMP-9	Cholestasis	Martínez-Rizo et al[97], Liver Int 2010
TGF-β	MMP-9	Warm ischemia	Feng et al[39], J Surg Res 2013
	MMP-13	Cholestasis	Aldaba-Muruato et al[98], Can J Physiol Pharmacol 2012
IL-10	MMP-2 and MMP-9	Warm ischemia	Feng et al[99], Int Immunopharmacol 2012

MMP: Matrix metalloproteinase; TNF-α: Tumor necrosis factor; iNOS: Inducible nitric oxide synthase; IL: Interleukin; IFNα-2a: Interferon α- 2a; TGF-β: Transforming growth factor β; FN: Fibronectin.