Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review

Table 1 Classification and characteristics of the main matrix metalloproteinases

MMP (class and number)	Name	Extracellular Matrix substrate
Collagenases
MMP-1	Collagenase 1	Collagen I, II, III, VII, VIII and X, gelatin, proteoglycans, tenascin, entactin
MMP-8	Collagenase 2	Collagen I, II, III, V, VIII and X, gelatin, aggrecan
MMP-13	Collagenase 3	Collagen I, II, III, IV, IX and X, fibronectin, gelatin, tenascin, aggrecan, osteonectin
Gelatinases
MMP-2	Gelatinase A	Collagen I, IV, V, VII, IX and X, gelatin, proteoglycans, elastin, fibronectin, laminin, aggrecan, versican, osteonectin
MMP-9	Gelatinase B	Collagen IV, V, VII, X and XIV, gelatin, proteoglycans, elastin, aggrecan, versican, osteonectin
Stromelysins
MMP-3	Stromelysins 1	Collagen III, IV, V, and IX, gelatin, proteoglycans, tenascin, fibronectin, laminin, aggrecan, versican, osteonectin
MMP-10	Stromelysins 2	Collagen III, IV and V, gelatin, proteoglycans, aggrecan, elastin, casein
MMP-11	Stromelysins 3	Collagen IV, fibronectin, laminin, gelatin, transferrin
Membrane type
MMP-14	MT1-MMP	Collagen I, II and III, fibronectin, vitronectin, tenascin, laminin, proteoglycans, aggrecan, elastin, casein, entactin
MMP-15	MT2-MMP	Fibronectin, tenascin, laminin
MMP-16	MT3-MMP	Collagen III, fibronectin, casein, gelatin
MMP-17	MT4-MMP	ND
MMP-24	MT5-MMP	Activator of proMMP-2
MMP-25	MT6-MMP	Collagen IV, fibronectin, gelatin, fibrinogen
Others
MMP-7		Collagen IV and X, gelatin, proteoglycans, tenascin, fibronectin, laminin, aggrecan, osteonectin, entactin, casein, tranferrin, integrin b4
MMP-12		Collagen IV, gelatin, proteoglycans, fibronectin, laminin, entactin, casein, vibronectin, elastin
MMP-19	ND	Aggrecan, cartilage oligomeric matrix protein (COMP)
MMP-20	Enamelysin	Amelogenin
MMP-23A	MMP-21	ND
MMP-23B	MMP-22	ND
MMP-26	Matrilysin 2	Collagen IV, fibronectin, casein, fibrinogen
MMP-27	ND	ND
MMP-28	Epilysin	Casein

ND: Not Determined; MMP: Matrix metalloproteinase.