Copyright
©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 12101-12113
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12101
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12101
Factors | Study design | Number of patients | Characteristics | Ref. | Comments |
Viral factors | |||||
High baseline viral load (> 8 × 105 UI/mL) | Prospective | 426 (all GT-3) | 223 patients with viral load > 8 × 105 UI/mL | [56] | Combined with non-RVR |
High baseline viral load (> 6 × 105 UI/mL) | Retrospective | 107 (all GT-3) | 45 non-SVR/62 SVR | [71] | Combined with advanced fibrosis |
High baseline quasi- species complexity and diversity | Retrospective | 10 (all GT-3) | [58] | ||
Mutations in NS5A | Prospective | 49 (all GT-3) | 25 non-SVR/24 SVR | [62] | Significant mutations at positions 2309 (Ala to Ser) and 2326 (Gly to Ala) |
Host factors | |||||
Fibrosis/Cirrhosis | Prospective | 91 (all GT-3) | 17 cirrhotic/74 non-cirrhotic | [63] | Also associated with increased risk of post-treatment relapse |
Retrospective | 604 (all GT-3) | 145 cirrhotic/459 non-cirrhotic | [64] | Response not affected by ethnicity | |
Retrospective | 180 | 108 GT-3/72 GT-2 | [66] | Lack of SVR associated with fibrosis and GT-3 | |
Retrospective | 107 (all GT-3) | 45 non-SVR/62 SVR | [71] | Combined with high baseline viral load | |
Steatosis | Prospective | 224 | 182 GT-3/42 GT-2 | [69] | Lower SVR in GT-3 |
Retrospective | 932 | 505 GT-3/427 GT-2 | [70] | Associated with higher relapse rates in GT-3 patients who had RVR | |
Ethnicity | Retrospective | 103 | 66 Caucasians/38 Asians | [74] | Poor response could reflect more advanced liver disease at baseline in Asian patients |
Retrospective | 604 (all GT-3) | 305 non-Asians/299 South Asians | [64] | No correlation between ethnicity and treatment relapse | |
IFNL3 gene polymorphisms | Retrospective | 107 (all GT-3) | 45 non-SVR/62 SVR | [71] | No correlation between IFNL3 polymorphisms and SVR |
Prospective | 293 HCV RNA- positive | 65.87% GT-3/32.08% GT-1 | [78] | CC and TT alleles strongly associated with SVR in GT-3 patients | |
Intrahepatic ISG15 expression/IFNL4 gene polymorphisms | Retrospective | 92 | 36 GT-3/56 GT-1 | [79] | In GT-3, low ISG15 expression and good-responder IFNL4 genotype associated with high SVR rates |
- Citation: Gondeau C, Pageaux GP, Larrey D. Hepatitis C virus infection: Are there still specific problems with genotype 3? World J Gastroenterol 2015; 21(42): 12101-12113
- URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12101.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12101