Application of nucleoside analogues to liver transplant recipients with hepatitis B

Table 1 Structure, mechanism of action, and incidence of resistance of currently available nucleoside analogues[12,20,21]

Drug name	Structure	Mechanism of action	Incidence of drug resistance
LAM	Cytidine analogue	Premature chain termination	High
LDT	Thymidine analogue		High
ETV	Guanosine analogue	Inhibits priming RT	Low
		Inhibit negative and positive strand synthesis
ADV	Adenosine analogue	Premature chain termination	High
TDF		Inhibit negative strand synthesis	Unknown

ADV: Adefovir dipivoxil; ETV: Entecavir; HBV: Hepatitis B virus; LAM: Lamivudine; LDT: Telbivudine; NA: Nucleoside analogue; RT: Reverse transcriptase; TDF: Tenofovir.